SCHEMBL8488334

SCHEMBL8488334

Nc1ccc(S(=O)(=O)ON2C(=O)c3ccccc3C2=O)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.75
ALDH1A1 P00352 9/20 0.75
MAPT P10636 9/20 0.75
KMT2A Q03164 8/20 0.75
HPGD P15428 7/20 0.75
MEN1 O00255 5/20 0.73
VDR P11473 3/20 0.73
F2 P00734 4/20 0.66
HTT P42858 3/20 0.59
LMNA P02545 3/20 0.55
THRB P10828 1/20 0.55
XBP1 P17861 2/20 0.51
CYP3A4 P08684 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
POLB P06746 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
PARL Q9H300 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL64368 0.86 KDM4E (1.00) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL64277 0.85 VDR (1.00) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL2468373 0.85 KMT2A (1.00) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL29370293 0.85 VDR (1.00) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL11025987 0.84 ALDH1A1 (0.71) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL8778106 0.83 KDM4E (0.76) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL7886651 0.83 KDM4E (0.75) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL27488406 0.83 KDM4E (0.74) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL5369841 0.81 VDR (0.74) KDM4EALDH1A1MAPTKMT2AHPGD
SCHEMBL22251611 0.80 KDM4E (0.75) KDM4EALDH1A1MAPTKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11174670-A None JP disclosed
JP-H11174670-A RESIST MATERIAL NEC CORP 1999-07-02 JP disclosed