Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | CDC25A | P30304 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28295668 | 0.78 | LMNA (0.41) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28486552 | 0.74 | PRKCG (0.37) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL10613637 | 0.69 | PTGS1 (0.53) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL5323524 | 0.67 | CES1 (0.53) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL28537893 | 0.67 | CES1 (0.45) | ALDH1A1LMNAMEN1KMT2AALDH2 | |
| SCHEMBL32677342 | 0.67 | NR1H2 (0.38) | ALDH1A1LMNASMN1; SMN2MAPK1ALDH2 | |
| SCHEMBL11036624 | 0.67 | ATM (0.46) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| Bromide SCHEMBL460851 | 0.64 | ALDH1A1 (0.47) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL4595897 | 0.64 | KMT2A (0.47) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL28461113 | 0.63 | TDP1 (0.39) | ALDH1A1LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939435-A | TREATMENT OF ATHEROSCLEROSIS AND CORONARY HEART DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-4194987-A | N-ACYL-CYANO-DIHYDRO(ISO)QUINOLINES AS ACTIVATORS | FMC CORPORATION (US) | 1980-03-25 | — | — | US | disclosed |