Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.44 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079902 | 0.77 | TSHR (0.46) | OPRM1OPRD1NPC1RAB9A | |
| SCHEMBL5722096 | 0.76 | OPRM1 (0.61) | OPRM1OPRK1OPRD1G6PC1HDAC1 | |
| SCHEMBL24045930 | 0.76 | G6PC1 (0.44) | OPRM1OPRK1OPRD1G6PC1SLC18A3 | |
| Hydrochloric Acid SCHEMBL9079845 | 0.75 | ALDH1A1 (0.44) | OPRM1OPRD1NPC1RAB9A | |
| SCHEMBL522763 | 0.73 | SLC18A3 (0.49) | OPRM1OPRK1OPRD1G6PC1HDAC1 | |
| SCHEMBL8773484 | 0.71 | HDAC1 (0.61) | HDAC1HDAC6ATMPTGESNPC1 | |
| SCHEMBL12126132 | 0.71 | OPRM1 (0.54) | OPRM1OPRK1OPRD1ATM | |
| SCHEMBL9178257 | 0.71 | TSHR (0.47) | NPC1RAB9A | |
| SCHEMBL9016960 | 0.70 | OPRM1 (0.53) | OPRM1OPRK1OPRD1G6PC1HDAC1 | |
| SCHEMBL9016964 | 0.70 | OPRM1 (0.53) | OPRM1OPRK1OPRD1G6PC1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5783593-A | FUNGICIDE; ANTICHOLESTEROL AGENT | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |