Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343532 | 1.00 | GRIK1 (0.54) | GRIK1PPARGPPARACNR1CNR2 | |
| SCHEMBL8502363 | 0.84 | GRIK1 (0.51) | GRIK1PPARGPPARACNR1CNR2 | |
| SCHEMBL7344629 | 0.83 | MMP12 (0.55) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL7922577 | 0.83 | PPARG (0.56) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL7353605 | 0.80 | PTGES (0.51) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL8481584 | 0.79 | MMP2 (0.53) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL7347169 | 0.79 | MMP2 (0.60) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL7352438 | 0.79 | MMP2 (0.60) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL7371830 | 0.79 | MMP2 (0.60) | GRIK1PPARGPPARAMMP2MMP3 | |
| SCHEMBL27463544 | 0.79 | SLC6A9 (0.44) | PPARGPPARACNR1CNR2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939583-A | ANTIARTHRITIC AGENTS; BONE, CARDIOVASCULAR, BRAIN, NERVOUS SYSTEM DISORDERS; ANTITUMOR AND ANTIMETASTASIS AGENTS | BAYER CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |