SCHEMBL8518603

SCHEMBL8518603

O=c1[nH]c(-c2ccsc2)cn1-n1c(-c2ccccc2)c[nH]c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLO1 Q04760 1/20 0.40
CYP2E1 P05181 1/20 0.37
CYP2A6 P11509 1/20 0.37
CYP2B6 P20813 1/20 0.37
CCNE1 P24864 1/20 0.35
CDK2 P24941 1/20 0.35
FYN P06241 1/20 0.33
CDK8 P49336 1/20 0.32
KDM4E B2RXH2 1/20 0.31
TSHR P16473 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
HSD17B10 Q99714 1/20 0.31
NPY5R Q15761 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
ERCC1 P07992 1/20 0.31
FEN1 P39748 1/20 0.31
ERCC4 Q92889 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8658246 0.83 CYP2E1 (0.47) GLO1CYP2E1CYP2A6CYP2B6FYN
SCHEMBL8660223 0.71 CYP2E1 (0.36) GLO1CYP2E1CYP2A6CYP2B6FYN
SCHEMBL8406497 0.68 ERCC1 (0.52) KDM4ENPSR1HSD17B10CA12CA1
SCHEMBL8488124 0.62 ALDH1A1 (0.37) CCNE1CDK2CDK8KDM4ENPSR1
SCHEMBL8987160 0.62 CYP2E1 (0.53) GLO1CYP2E1CYP2A6CYP2B6CDK8
SCHEMBL8408833 0.61 GSK3B (0.40) CYP2E1CYP2A6CYP2B6CCNE1CDK2
SCHEMBL4736133 0.60 RAB9A (0.69) KDM4ECA12CA1CA2CA9
SCHEMBL12407928 0.59 NPC1 (0.58) CCNE1CDK2KDM4EHSD17B10NPC1
SCHEMBL4232792 0.59 ALDH1A1 (0.65) KDM4ETSHRNPSR1NPC1ALDH1A1
SCHEMBL14417266 0.59 DRD2 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927192-A1 MODIFIED AMINOACIDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND METHOD FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1999-07-07 EP claimed
WO-1998011128-A1 MODIFIED AMINOACIDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND METHOD FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1998-03-19 WO claimed
EP-0927192-A1 MODIFIED AMINOACIDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND METHOD FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1999-07-07 EP disclosed
WO-1998011128-A1 MODIFIED AMINOACIDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND METHOD FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1998-03-19 WO disclosed