Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518458 | 0.89 | PTGS2 (0.55) | LMNAALDH1A1KDM4EABCB11PTGS2 | |
| SCHEMBL8519156 | 0.82 | OPRK1 (0.46) | LMNAALDH1A1ABCB11PTGS2MEN1 | |
| SCHEMBL8519556 | 0.76 | ABCB11 (0.47) | LMNAALDH1A1ABCB11PTGS2PPARG | |
| SCHEMBL8519457 | 0.74 | GAA (0.48) | ALDH1A1GAAMMP1MMP9MMP13 | |
| SCHEMBL8519558 | 0.73 | ABCB11 (0.43) | LMNAALDH1A1ABCB11PTGS2MEN1 | |
| SCHEMBL8518786 | 0.73 | ABCB11 (0.43) | LMNAALDH1A1ABCB11PTGS2MEN1 | |
| SCHEMBL8519811 | 0.73 | ABCB11 (0.48) | LMNAALDH1A1ABCB11PTGS2MEN1 | |
| SCHEMBL7473702 | 0.73 | PTGS2 (0.56) | LMNAALDH1A1KDM4EABCB11PTGS2 | |
| SCHEMBL8518402 | 0.72 | ABCB11 (0.47) | LMNAALDH1A1KDM4EABCB11PTGS2 | |
| SCHEMBL8519157 | 0.72 | ABCB11 (0.43) | LMNAALDH1A1ABCB11PTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |