Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666469 | 0.90 | MAPT (0.44) | GPR119MEN1KMT2AALDH1A1PIK3CA | |
| SCHEMBL8325925 | 0.85 | THRB (0.44) | KMT2AMAPTGAAPTPN2PTPN1 | |
| SCHEMBL8666467 | 0.84 | SMN1; SMN2 (0.45) | GPR119MEN1KMT2AALDH1A1PIK3CA | |
| SCHEMBL8605663 | 0.79 | GPR119 (0.39) | GPR119KMT2AALDH1A1PIK3CAPRKDC | |
| SCHEMBL8662409 | 0.79 | MAPT (0.54) | MEN1KMT2AALDH1A1TP53MAPT | |
| SCHEMBL7452056 | 0.77 | MCL1 (0.52) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL8321803 | 0.77 | HDAC8 (0.41) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL6189754 | 0.74 | GPR119 (0.64) | GPR119ALDH1A1 | |
| SCHEMBL8664948 | 0.73 | TP53 (0.48) | GPR119KMT2AALDH1A1PIK3CAPRKDC | |
| SCHEMBL1222027 | 0.71 | KMT2A (0.57) | GPR119MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912175-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-09-08 | — | — | EP | disclosed |
| EP-0912175-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5854245-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-12-29 | — | — | US | disclosed |
| WO-1998000134-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-01-08 | — | — | WO | disclosed |