SCHEMBL8523571

SCHEMBL8523571

C=CCN1CNc2cc(C(F)(F)F)ccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.43
MEN1 O00255 3/20 0.43
GAA P10253 3/20 0.43
KDM4E B2RXH2 3/20 0.43
MAPT P10636 2/20 0.43
ALDH1A1 P00352 4/20 0.35
MAPK1 P28482 2/20 0.35
GRIA1 P42261 1/20 0.35
GRIA2 P42262 1/20 0.35
GRIA3 P42263 1/20 0.35
GRIA4 P48058 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PKM P14618 1/20 0.33
LMNA P02545 3/20 0.33
AR P10275 2/20 0.32
HDAC1 Q13547 1/20 0.32
ADRB2 P07550 1/20 0.32
NCF1 P14598 1/20 0.32
NOTUM Q6P988 1/20 0.31
CYBB P04839 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8523950 0.80 GRIA2 (0.37) GAAKDM4EMAPTALDH1A1GRIA1
SCHEMBL8469492 0.77 GRIA2 (0.43) KMT2AMEN1GAAKDM4EMAPT
SCHEMBL8524767 0.73 HRH3 (0.40) GAAKDM4EALDH1A1MAPK1GRIA1
SCHEMBL8523029 0.73 DRD2 (0.37) KMT2AMEN1KDM4EMAPTALDH1A1
SCHEMBL7544166 0.73 GAA (0.42) KMT2AMEN1GAAKDM4EMAPT
SCHEMBL8469923 0.70 GRIA1 (0.44) KDM4EALDH1A1GRIA1GRIA2GRIA3
SCHEMBL11347344 0.70 MAPT (0.45) KMT2AMEN1GAAKDM4EMAPT
SCHEMBL18638342 0.68 KIF11 (0.36) KMT2AMEN1GAAKDM4EMAPT
SCHEMBL5331050 0.68 KMT2A (0.43) KMT2AMEN1GAAKDM4EMAPT
SCHEMBL18638664 0.67 APP (0.42) HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5968725-A MATERIAL COMPRISING ON SUPPORT SILVER HALIDE PHOTOSENSITIVE LAYER CONTAINING ORGANIC SILVER SALT, REDUCING AGENT, ULTRAHIGH CONTRAST PROMOTING AGENT, SELECTED HETEROCYCLIC MERCAPTO COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1999-10-19 US disclosed
US-5236807-A Negative, hydrazine compound FUJI PHOTO FILM CO., LTD. (JP) 1993-08-17 US disclosed
US-4769316-A Method for restraining the formation of re-reversal negative image in direct positive silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1988-09-06 US disclosed