Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529533 | 0.90 | DRD2 (0.40) | HTTDRD2DRD3SMN1; SMN2GLA | |
| Hydrochloric Acid SCHEMBL9091515 | 0.89 | DRD2 (0.39) | HTTDRD2DRD3SMN1; SMN2GLA | |
| SCHEMBL8529262 | 0.82 | SIGMAR1 (0.48) | DRD2DRD3 | |
| SCHEMBL8525974 | 0.79 | PRMT5 (0.51) | HTTDRD2DRD3SMN1; SMN2HPGD | |
| SCHEMBL11399774 | 0.77 | HTT (0.40) | HTTDRD2SMN1; SMN2GLAHPGD | |
| SCHEMBL8967277 | 0.76 | ALDH1A1 (0.54) | HTTDRD2DRD3SMN1; SMN2HPGD | |
| SCHEMBL8526354 | 0.76 | DRD2 (0.43) | DRD2DRD3SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL7443000 | 0.75 | TSHR (0.49) | SMN1; SMN2HPGDALDH1A1CYP3A4PKM | |
| SCHEMBL8527910 | 0.74 | DRD2 (0.48) | HTTDRD2DRD3SMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL8528647 | 0.73 | DRD2 (0.47) | HTTDRD2DRD3SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |