Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525857 | 0.84 | HTR2B (0.40) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL8527235 | 0.77 | KMT2A (0.46) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL8528166 | 0.77 | P2RX7 (0.37) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL6268738 | 0.67 | TSHR (0.41) | MEN1KMT2AAADATGAAALDH1A1 | |
| SCHEMBL8475138 | 0.67 | KMT2A (0.64) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL8528512 | 0.65 | DPP4 (0.39) | MEN1KMT2AALDH1A1PABPC1DPP4 | |
| SCHEMBL8526296 | 0.65 | MEN1 (0.51) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL10568945 | 0.63 | ALDH1A1 (0.51) | MEN1KMT2AAADATGAATP53 | |
| SCHEMBL10568980 | 0.63 | ALDH1A1 (0.51) | MEN1KMT2AAADATGAATP53 | |
| SCHEMBL8664646 | 0.62 | ALDH1A1 (0.41) | HTR2BOPRM1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | claimed |