Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525857 | 0.92 | HTR2B (0.40) | MEN1KMT2AHRH2OPRM1HTR2B | |
| SCHEMBL8527235 | 0.87 | KMT2A (0.46) | P2RX7MEN1KMT2AHRH2OPRM1 | |
| SCHEMBL8664646 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AOPRM1HTR2BL3MBTL1 | |
| SCHEMBL8526252 | 0.77 | HTR2B (0.37) | MEN1KMT2AHRH2OPRM1HTR2B | |
| SCHEMBL8528545 | 0.76 | MEN1 (0.42) | MEN1KMT2AHTR2B | |
| SCHEMBL8526108 | 0.76 | ALDH1A1 (0.42) | P2RX7OPRM1HTR2BPABPC1 | |
| SCHEMBL8528512 | 0.75 | DPP4 (0.39) | P2RX7MEN1KMT2APABPC1LMNA | |
| SCHEMBL10570442 | 0.73 | ALDH1A1 (0.44) | P2RX7MEN1KMT2APOLB | |
| SCHEMBL10565721 | 0.72 | ALDH1A1 (0.43) | P2RX7MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL8525685 | 0.71 | MGLL (0.41) | MEN1KMT2APABPC1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |