Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527235 | 0.85 | KMT2A (0.46) | DPP4ANPEPLMNAP2RX7CRHBP | |
| SCHEMBL8527036 | 0.82 | FAAH (0.46) | DPP4NR1H2NR1H3ANPEPLMNA | |
| SCHEMBL8525857 | 0.79 | HTR2B (0.40) | DPP4ANPEPPABPC1KMT2AMEN1 | |
| SCHEMBL8528166 | 0.75 | P2RX7 (0.37) | LMNAP2RX7PABPC1KMT2AMEN1 | |
| SCHEMBL8475825 | 0.71 | POLB (0.47) | DPP4NR1H2NR1H3ANPEPLMNA | |
| SCHEMBL8476116 | 0.70 | KMT2A (0.54) | DPP4NR1H2NR1H3ANPEPLMNA | |
| SCHEMBL8525685 | 0.69 | MGLL (0.41) | LMNANPSR1PABPC1KMT2AMEN1 | |
| SCHEMBL29382416 | 0.69 | DPP4 (0.61) | DPP4NR1H2NR1H3ANPEPLMNA | |
| SCHEMBL8526206 | 0.68 | MEN1 (0.44) | DPP4NR1H2NR1H3ANPEPLMNA | |
| SCHEMBL8526252 | 0.65 | HTR2B (0.37) | DPP4ANPEPPABPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | claimed |