Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528932 | 0.86 | XDH (0.40) | KDM4EALDH1A1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8529278 | 0.83 | SLC9A1 (0.42) | KDM4EALDH1A1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8529538 | 0.78 | PTGS2 (0.41) | KMT2ALMNAHPGDCYP1A2CYP2C9 | |
| SCHEMBL29788088 | 0.76 | AKR1C2 (0.41) | KDM4EALDH1A1KMT2ASMN1; SMN2GRIA4 | |
| SCHEMBL8529462 | 0.75 | FOLH1 (0.40) | ALDH1A1SMN1; SMN2PTGS2HNF4AFOLH1 | |
| SCHEMBL8529625 | 0.74 | PTGS2 (0.38) | KDM4EALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL28153772 | 0.74 | HNF4A (0.54) | KDM4EALDH1A1KMT2ASMN1; SMN2GAA | |
| SCHEMBL8610258 | 0.74 | PTGS2 (0.39) | ALDH1A1SMN1; SMN2LMNAPTGS2 | |
| SCHEMBL16911507 | 0.73 | HNF4A (0.58) | KDM4EALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5026544 | 0.73 | FOLH1 (0.43) | KDM4EALDH1A1KMT2ASMN1; SMN2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699660-B1 | Arylbenzoylguanidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5807896-A | Arylbenzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 1998-09-15 | — | — | US | disclosed |
| EP-0699660-A2 | Arylbenzoylguanidines | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |