Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 2/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529462 | 0.87 | FOLH1 (0.40) | FOLH1CA9MAPTMAPK1PKM | |
| SCHEMBL28016227 | 0.87 | GABRP (0.40) | CA9LTB4RLTB4R2MCL1 | |
| SCHEMBL8533081 | 0.84 | SLC9A1 (0.40) | — | |
| SCHEMBL8534063 | 0.78 | CA1 (0.42) | FOLH1CA1CA2CA9MAPT | |
| SCHEMBL28379211 | 0.77 | HNF4A (0.46) | FOLH1MAPTMAPK1PKMSMN1; SMN2 | |
| SCHEMBL8533064 | 0.77 | PTGS1 (0.40) | CA1CA2CA9SMN1; SMN2MCL1 | |
| SCHEMBL29226029 | 0.75 | HNF4A (0.56) | CA1CA2CA9MAPTPKM | |
| SCHEMBL30153392 | 0.75 | HNF4A (0.56) | CA1CA2CA9MAPTPKM | |
| SCHEMBL8530215 | 0.74 | MEN1 (0.39) | FOLH1CA1CA2CA9MAPT | |
| SCHEMBL8528932 | 0.74 | XDH (0.40) | FOLH1CA1CA2CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1055919-C | Arylbenzoylguanidin | MERCK PATENT GMBH (DE) | 2000-08-30 | — | — | CN | disclosed |
| EP-0699660-B1 | Arylbenzoylguanidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5807896-A | Arylbenzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 1998-09-15 | — | — | US | disclosed |
| EP-0699660-A2 | Arylbenzoylguanidines | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |
| CN-1117962-A | Arylbenzoylguanidin | MERCK PATENT GMBH (DE) | 1996-03-06 | — | — | CN | disclosed |