SCHEMBL8534702

SCHEMBL8534702

Cc1ccc(CCC(N)=O)cc1C

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CAPN1 P07384 1/20 0.46
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
CNR1 P21554 1/20 0.43
FFAR1 O14842 2/20 0.43
FFAR4 Q5NUL3 2/20 0.42
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
HSD17B10 Q99714 1/20 0.41
SLC22A12 Q96S37 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
IAPP P10997 1/20 0.40
IDO1 P14902 1/20 0.39
POLB P06746 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2091468 0.91 SKP2 (0.44) ALDH1A1CNR1USP2ALOX15CASP1
SCHEMBL28659512 0.85 ESR1 (0.55) CAPN1ALDH1A1LMNAFFAR1IAPP
SCHEMBL28106880 0.84 IAPP (0.53) CNR1FFAR1FFAR4CYP1A2CYP3A4
SCHEMBL26937838 0.84 SLC22A12 (0.47) CAPN1ALDH1A1LMNAFFAR1FFAR4
SCHEMBL26937826 0.84 DAO (0.47) CAPN1ALDH1A1LMNAFFAR1FFAR4
SCHEMBL585013 0.82 FFAR4 (0.58) ALDH1A1FFAR1FFAR4
SCHEMBL4632516 0.82 ALDH1A1 (0.53) ALDH1A1LMNACNR1FFAR1FFAR4
SCHEMBL6938279 0.81 CNR1 (0.47) CNR1FFAR1FFAR4IAPPPOLB
SCHEMBL2702346 0.80 CA2 (0.52) ALDH1A1LMNAUSP2ALOX15CASP1
SCHEMBL28780839 0.80 L3MBTL1 (0.49) CAPN1ALDH1A1LMNAFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4360710-A2 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT Korea Research Institute of Chemical Technology (KR) 2024-05-01 EP disclosed
EP-3611158-B1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT KOREA RES INST CHEMICAL TECH (KR) 2023-12-20 EP disclosed
EP-4074701-B1 NOVEL AMIDE DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF LG CHEMICAL LTD (KR) 2023-12-13 EP disclosed
WO-2020039732-A1 CELL AGGREGATION INCLUDING OLFACTORY NEURON OR PRECURSOR CELL THEREOF, AND METHOD FOR PRODUCING SAME 住友化学株式会社 2020-02-27 WO disclosed
EP-3611158-A1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT Korea Research Institute of Chemical Technology (KR) 2020-02-19 EP disclosed
EP-2722322-B1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT KOREA RES INST CHEMICAL TECH (KR) 2019-06-12 EP disclosed
US-9833423-B2 1,3-Di-oxo-indene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method thereof, and pharmaceutical composition containing same as an antiviral, active ingredient KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2017-12-05 US disclosed
US-20160272564-A1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D (BE) 2016-09-22 US disclosed
US-9346749-B2 1,3-di-oxo-indene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method thereof, and pharmaceutical composition containing same as an antiviral, active ingredient KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2016-05-24 US disclosed
US-20140121187-A1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D (BE) 2014-05-01 US disclosed
EP-2722322-A2 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT Korea Research Institute of Chemical Technology (KR) 2014-04-23 EP disclosed
EP-0721939-B1 N-arylalkylphenylacetamide derivatives KOREA RES INST CHEM TECH (KR) 1998-04-15 EP disclosed
US-5670546-A ANALGESICS, ANTIINFLAMMATORY AGENTS, RELATED TO CAPSAICIN BUT WITHOUT UNDESIRABLE SIDE EFFECTS KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1997-09-23 US disclosed
EP-0721939-A1 N-arylalkylphenylacetamide derivatives Korea Research Institute of Chemical Technology (KR) 1996-07-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160272564-A1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT RNASE1, PEAK1, PARK7 CAPN1 787/4885ALDH1A1 3359/4885LMNA 3508/4885
US-20140121187-A1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT RNASE1, PARK7, PEAK1 CAPN1 1662/4885ALDH1A1 2866/4885LMNA 3598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.