Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11955707 | 0.85 | HTR3E (0.58) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11162862 | 0.83 | RAD52 (0.50) | ALDH1A1MAPTTSHR | |
| SCHEMBL4355720 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL4255355 | 0.79 | ALDH1A1 (0.59) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11214293 | 0.78 | HTR1A (0.56) | ALDH1A1LMNASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL6714846 | 0.78 | ALDH1A1 (0.75) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11100857 | 0.78 | ALDH1A1 (0.75) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8128745 | 0.77 | HTR3E (0.53) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8686716 | 0.76 | LMNA (0.52) | KCNH2ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL6412443 | 0.75 | MCOLN2 (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739334-A | CHEMICAL INTERMEDIATES FOR NEW ANTIDEPRESSANT WITH SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |
| US-5726178-A | Alkyl derivatives of trazodone with CNS activity | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-03-10 | — | — | US | disclosed |
| EP-0623131-B1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ANGELINI RICERCHE SPA (IT) | 1996-04-03 | — | — | EP | disclosed |
| EP-0623131-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY. | ANGELINI FRANCESCO IST RICERCA (IT) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014091-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1993-07-22 | — | — | WO | disclosed |