SCHEMBL85365

SCHEMBL85365

Cc1c(C)c(Cl)c(Cl)c(Cl)c1C

nearest known ligand 0.31

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10584467 0.95 CYP3A4 (0.30)
SCHEMBL31831117 0.95 MEN1 (0.33) MEN1ALDH1A1LMNAMAPTHPGD
SCHEMBL1006950 0.95 MEN1 (0.33) MEN1ALDH1A1LMNAMAPTHPGD
SCHEMBL11501561 0.86 CYP3A4 (0.30)
SCHEMBL1004507 0.86 MEN1 (0.33) MEN1ALDH1A1LMNAMAPTHPGD
SCHEMBL11751623 0.82
SCHEMBL9843033 0.82
SCHEMBL631112 0.82 MEN1 (0.31) MEN1ALDH1A1LMNAMAPTHPGD
SCHEMBL2749936 0.80 CYP3A4 (0.32) MEN1ALDH1A1MAPTKMT2A
SCHEMBL1004982 0.80 CYP3A4 (0.32) MEN1ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108348448-A Oil-in-water type organopolysiloxane emulsion, its manufacturing method, cosmetic material and cosmetics 道康宁东丽株式会社 2018-07-31 CN disclosed
US-8802070-B2 Compositions containing a phospholipid, a nonionic surfactant, and an anionic silicone for lifting color and/or imparting shine onto keratinous substrates L'OREAL (FR) 2014-08-12 US disclosed
US-8795645-B2 Compositions containing a fatty quaternary amine, a nonionic surfactant, and an anionic silicone for lifting color and/or imparting shine onto keratinous substrates L'OREAL (FR) 2014-08-05 US disclosed
US-8648023-B2 Process for inhibiting dyed hair fibers from losing their color during shampooing L'ORÉAL (FR) 2014-02-11 US disclosed
US-8637489-B2 Clear carrier compositions for lipophilic compounds, and method of treating keratinous substrates using such compositions L'OREAL (FR) 2014-01-28 US disclosed
US-8529636-B2 Emulsion dyeing composition containing at least one phospholipid, at least one nonionic surfactant and at least one silicone, and method of using same L'OREAL (FR) 2013-09-10 US disclosed
US-8524206-B2 Aqueous polyamine-containing carrier systems for water-insoluble materials L'OREAL (FR) 2013-09-03 US disclosed
US-8523954-B2 Emulsion dyeing composition containing at least one polyamine, at least one nonionic surfactant and at least one silicone, and method of using same L'OREAL (FR) 2013-09-03 US disclosed
US-8523955-B2 Emulsion dyeing composition containing at least one fatty quaternary amine, at least one nonionic surfactant and at least one silicone, and method of using same L'OREAL (FR) 2013-09-03 US disclosed
US-8475778-B2 behentrimonium chloride; (a) fatty quaternary amine; (b) nonionic surfactant; (c)anionic silicone; (d) water insoluble material; (e) cationic polymer; (f) film former; inhibiting water loss or absorption from hair fibers upon exposure humidity L'OREAL (FR) 2013-07-02 US disclosed
US-7608569-B2 Antifrizz; with anionic silicone such as silicone phosphate, and film forming polymer; shampoos, hair conditioners, hair styling products L'ORÉAL (FR) 2009-10-27 US disclosed
US-7449029-B2 Composition and process for color hair L'OREAL (FR) 2008-11-11 US disclosed
US-20080085258-A1 Aqueous polymaine-containing anti-frizz composition for hair L'OREAL (FR) 2008-04-10 US disclosed
US-20080085254-A1 (a) lecithin (b) nonionic surfactant; (c)anionic silicone; (d) water insoluble material; (e) cationic polymer; (f) film former; inhibiting water loss or absorption from hair fibers upon exposure humidity L'OREAL (FR) 2008-04-10 US disclosed
US-20080085253-A1 Aqueous polyamine-containing anti-frizz composition for hair L'OREAL (FR) 2008-04-10 US disclosed
US-20080085255-A1 (a) C12-C22 tertiary amidoamine (b) nonionic surfactant; (c)anionic silicone; (d) water insoluble material; (e) cationic polymer; (f) film former; inhibiting water loss or absorption from hair fibers upon exposure humidity; stearamidopropyldimethylamine L'OREAL (FR) 2008-04-10 US disclosed
US-20070110691-A1 Process for inhibiting dyed hair fibers from losing their color during shampooing L'OREAL (FR) 2007-05-17 US disclosed
US-20070107141-A1 Process for styling dyed hair and inhibiting its color loss during shampooing L'OREAL (FR) 2007-05-17 US disclosed
US-20070110690-A1 Process for inhibiting hair from becoming frizzy L'OREAL (FR) 2007-05-17 US disclosed
US-20070107142-A1 Composition and process for coloring hair L'OREAL (FR) 2007-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070107141-A1 Process for styling dyed hair and inhibiting its color loss during shampooing SRM, SMS, SUCLG1 MEN1 369/4885ALDH1A1 3843/4885LMNA 545/4885
US-20070110691-A1 Process for inhibiting dyed hair fibers from losing their color during shampooing SRM, SMS, SMOX MEN1 875/4885ALDH1A1 2860/4885LMNA 434/4885
US-20080085254-A1 (a) lecithin (b) nonionic surfactant; (c)anionic silicone; (d) water insoluble material; (e) cationic polymer; (f) film former; inhibiting water loss or absorption from hair fibers upon exposure humidity SGMS1, PHOSPHO1, SGMS2 MEN1 457/4885ALDH1A1 4502/4885LMNA 353/4885
US-20080085253-A1 Aqueous polyamine-containing anti-frizz composition for hair SHH, SRM, FZD7 MEN1 777/4885ALDH1A1 3411/4885LMNA 2263/4885
US-20080085255-A1 (a) C12-C22 tertiary amidoamine (b) nonionic surfactant; (c)anionic silicone; (d) water insoluble material; (e) cationic polymer; (f) film former; inhibiting water loss or absorption from hair fibers upon exposure humidity; stearamidopropyldimethylamine SGMS2, DRD2, H1-2 MEN1 1359/4885ALDH1A1 2575/4885LMNA 604/4885
US-20070110690-A1 Process for inhibiting hair from becoming frizzy SHH, SMO, SRM MEN1 354/4885ALDH1A1 2707/4885LMNA 1897/4885
US-20080085258-A1 Aqueous polymaine-containing anti-frizz composition for hair FZD7, SRM, MATR3 MEN1 760/4885ALDH1A1 4660/4885LMNA 2560/4885
US-20070107142-A1 Composition and process for coloring hair SRM, SMOX, SMS MEN1 848/4885ALDH1A1 1771/4885LMNA 763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.