Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532144 | 0.92 | TUBB4A (0.40) | MAT2ACYP19A1RHEBTACR1DHODH | |
| SCHEMBL8537070 | 0.84 | MAT2A (0.57) | CYP1A2POLBCYP3A4CYP2C9TSHR | |
| SCHEMBL8512624 | 0.82 | ALOX5 (0.50) | MAT2A | |
| SCHEMBL8537300 | 0.81 | KIF11 (0.46) | MAT2ATACR1DHODHKMT2AKIF11 | |
| SCHEMBL8514278 | 0.78 | KIF11 (0.42) | MAT2ATACR1DHODHKMT2AKIF11 | |
| SCHEMBL8535303 | 0.77 | MAT2A (0.55) | CYP3A4MAT2ACYP19A1RHEBKIF11 | |
| SCHEMBL8514142 | 0.75 | ALOX5 (0.48) | — | |
| SCHEMBL8530791 | 0.72 | MAT2A (0.43) | CYP1A2MAT2ADHODHKIF11PDE10A | |
| SCHEMBL8533188 | 0.71 | MAT2A (0.62) | MAT2ACYP19A1RHEBDHODHKIF11 | |
| SCHEMBL18412690 | 0.71 | SLC2A1 (0.42) | CYP1A2POLBCYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |