Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | HPGD | P15428 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | CTSV | O60911 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535774 | 0.87 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL8538008 | 0.84 | CTSV (0.63) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL20983235 | 0.84 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL8531701 | 0.82 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL8535103 | 0.76 | TUBB4A (0.48) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL8534119 | 0.76 | IMPDH2 (0.44) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL26847003 | 0.75 | HPGD (0.68) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL8535293 | 0.72 | MAT2A (0.48) | NPC1 | |
| SCHEMBL8532528 | 0.72 | MAT2A (0.48) | NPC1 | |
| SCHEMBL8535303 | 0.70 | MAT2A (0.55) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |