Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CTSV | O60911 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20983235 | 0.91 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8531701 | 0.89 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8537802 | 0.87 | KDM4E (0.44) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8538008 | 0.85 | CTSV (0.63) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8538462 | 0.79 | MAT2A (0.52) | NPC1CTSVCTSL | |
| SCHEMBL8534119 | 0.77 | IMPDH2 (0.44) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL8535103 | 0.77 | TUBB4A (0.48) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL26847003 | 0.76 | HPGD (0.68) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL312025 | 0.73 | KDM4E (0.51) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8535293 | 0.71 | MAT2A (0.48) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |