SCHEMBL8538202

SCHEMBL8538202

O=[N+]([O-])c1ccc(C#Cc2ccc(-c3nnn[nH]3)cc2)s1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.32
PGR P06401 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8815587 0.73 MMP2 (0.31)
SCHEMBL8716896 0.73 CYP2A6 (0.45) CYP2A6PGR
SCHEMBL8532934 0.73 FBP1 (0.39) PGR
SCHEMBL15177264 0.73 MEN1 (0.46)
SCHEMBL264644 0.71 XDH (0.51)
SCHEMBL8539025 0.70 KMT2A (0.34) CYP2A6
SCHEMBL12208052 0.70 MMP2 (0.43) CYP2A6
SCHEMBL12208232 0.70 DRD5 (0.40)
SCHEMBL8538200 0.68 KCNJ1 (0.41)
SCHEMBL2028396 0.66 ADH5 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726195-A Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents CUBIST PHARMACEUTICALS, INC. (US) 1998-03-10 US disclosed
WO-1997005132-A1 AMINOACYL ADENYLATE MIMICS AS NOVEL ANTIMICROBIAL AND ANTIPARASITIC AGENTS CUBIST PHARMACEUTICALS, INC. (US) 1997-02-13 WO disclosed