Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540504 | 0.88 | ACHE (0.33) | MAPTHTTSMN1; SMN2MCOLN3ACHE | |
| SCHEMBL8543171 | 0.86 | TXNRD1 (0.39) | MAPTHTTSMN1; SMN2MCOLN3ACHE | |
| SCHEMBL27375865 | 0.86 | MAPT (0.34) | MAPTHTTSMN1; SMN2MCOLN3ACHE | |
| SCHEMBL6932471 | 0.84 | SLC9A1 (0.46) | — | |
| SCHEMBL8542221 | 0.83 | TXNRD1 (0.41) | MAPTHTTSMN1; SMN2MCOLN3THRB | |
| SCHEMBL8542808 | 0.83 | TXNRD1 (0.37) | MAPTHTTSMN1; SMN2MCOLN3ALDH1A1 | |
| SCHEMBL8538162 | 0.82 | TXNRD1 (0.41) | MAPTHTTSMN1; SMN2THRBALDH1A1 | |
| SCHEMBL8538600 | 0.82 | TXNRD1 (0.41) | MAPTHTTSMN1; SMN2THRBALDH1A1 | |
| SCHEMBL8542782 | 0.81 | SLC9A1 (0.40) | — | |
| SCHEMBL8541311 | 0.78 | TAS1R3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |