Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 8/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538439 | 0.90 | CYP19A1 (0.35) | PGRCYP19A1 | |
| SCHEMBL10449145 | 0.83 | CYP19A1 (0.39) | CYP19A1 | |
| SCHEMBL8542951 | 0.81 | PGR (0.41) | PGRCYP17A1CYP19A1CYP21A2CYP1B1 | |
| SCHEMBL10697075 | 0.81 | CYP19A1 (0.38) | CYP19A1 | |
| SCHEMBL8536623 | 0.79 | PGR (0.39) | PGRCYP17A1CYP19A1CYP21A2 | |
| SCHEMBL8535933 | 0.75 | PGR (0.41) | PGRCYP17A1CYP19A1CYP21A2CYP1B1 | |
| SCHEMBL3356889 | 0.74 | CYP19A1 (0.44) | CYP19A1GRIN1GRIN2B | |
| SCHEMBL9948623 | 0.73 | CYP19A1 (0.44) | CYP19A1 | |
| SCHEMBL6301569 | 0.72 | CYP19A1 (0.44) | CYP19A1 | |
| SCHEMBL4945163 | 0.72 | SHBG (0.48) | CYP19A1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843933-A | 11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-01 | — | — | US | disclosed |
| US-5728689-A | ANTIGESTAGENIC EFFECT | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |