SCHEMBL8545335

SCHEMBL8545335

O=C(Cc1ccccc1)N1CCC(CCn2ccnc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.54
HDAC4 P56524 1/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC2 Q92769 1/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC11 Q96DB2 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
HDAC9 Q9UKV0 1/20 0.54
HDAC5 Q9UQL6 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.52
TACR3 P29371 1/20 0.52
FAAH O00519 1/20 0.52
GRIN2B Q13224 1/20 0.47
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 2/20 0.46
TBXAS1 P24557 1/20 0.46
POLB P06746 1/20 0.46
CYP19A1 P11511 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8540312 0.89 GRIN2B (0.55) FAAHGRIN2BALDH1A1KDM4ETBXAS1
SCHEMBL8538696 0.87 FAAH (0.50) FAAHGRIN2BALDH1A1KDM4ETBXAS1
SCHEMBL8540527 0.83 HDAC3 (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8541116 0.82 FAAH (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8545247 0.81 USP7 (0.52) ALDH1A1TBXAS1POLBCYP19A1SMN1; SMN2
SCHEMBL9031024 0.80 PKM (0.53) FAAHGRIN2BALDH1A1KDM4EPOLB
SCHEMBL8699553 0.79 PKM (0.52) TBXAS1CYP19A1SMN1; SMN2
SCHEMBL8545842 0.78 CCR3 (0.56)
SCHEMBL8540403 0.78 TBXAS1 (0.46) FAAHGRIN2BTBXAS1CYP19A1CYP11B1
SCHEMBL8545661 0.78 GRIN2B (0.46) FAAHGRIN2BALDH1A1TBXAS1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0705258-B1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY KNOLL AG (DE) 1998-12-30 EP disclosed
EP-0705258-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY Knoll AG (DE) 1996-04-10 EP disclosed
WO-1995000507-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY KNOLL AG (DE) 1995-01-05 WO disclosed