Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.37 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545901 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2TRPM8CDC7DBF4KDM4E | |
| SCHEMBL8549346 | 0.81 | LMNA (0.53) | SMN1; SMN2NPC1HPGDRAB9ATRPM8 | |
| SCHEMBL8545049 | 0.79 | MEN1 (0.35) | SMN1; SMN2NPC1HPGDRAB9ATRPM8 | |
| SCHEMBL8546712 | 0.78 | L3MBTL1 (0.45) | SMN1; SMN2NPC1RAB9ATRPM8KDM4E | |
| SCHEMBL8666788 | 0.78 | TRPM8 (0.41) | SMN1; SMN2NPC1HPGDRAB9ATRPM8 | |
| SCHEMBL8591219 | 0.77 | KDM5B (0.44) | SMN1; SMN2NPC1RAB9AKDM4EKDM6B | |
| SCHEMBL8673850 | 0.77 | ALDH1A1 (0.41) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL8551379 | 0.77 | KDM4E (0.49) | SMN1; SMN2NPC1HPGDRAB9ATRPM8 | |
| SCHEMBL8546592 | 0.76 | ALDH1A1 (0.40) | SMN1; SMN2NPC1HPGDRAB9ATRPM8 | |
| SCHEMBL8545256 | 0.75 | TRPM8 (0.42) | SMN1; SMN2NPC1HPGDRAB9ATRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |