Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548442 | 0.83 | HTR1F (0.48) | HTR1FMAPTTP53SMN1; SMN2KMT2A | |
| SCHEMBL8552580 | 0.82 | HTR1F (0.65) | HTR1FMAPTTP53SMN1; SMN2KMT2A | |
| SCHEMBL8548549 | 0.76 | HTR1F (0.50) | HTR1FMAPTTP53SMN1; SMN2HTR1A | |
| SCHEMBL8547488 | 0.71 | HTR1F (0.53) | HTR1FMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8552089 | 0.71 | HTR1F (0.52) | HTR1FMAPTTP53SMN1; SMN2KMT2A | |
| SCHEMBL3862378 | 0.69 | TP53 (0.54) | HTR1FMAPTTP53SMN1; SMN2KMT2A | |
| SCHEMBL8549636 | 0.69 | HTR1F (0.51) | HTR1FMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8549211 | 0.69 | HTR1F (0.49) | HTR1FMAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL4182497 | 0.68 | ROCK2 (0.68) | TP53SMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL4182502 | 0.68 | ROCK2 (0.68) | TP53SMN1; SMN2KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |