Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547488 | 0.87 | HTR1F (0.53) | HTR1FLMNASMN1; SMN2HSD17B10L3MBTL1 | |
| SCHEMBL8552580 | 0.87 | HTR1F (0.65) | HTR1FALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL8549838 | 0.83 | ALDH1A1 (0.47) | HTR1FALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8552436 | 0.81 | KMT2A (0.49) | ALDH1A1LMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8548295 | 0.80 | RAB9A (0.51) | ALDH1A1LMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8552089 | 0.78 | HTR1F (0.52) | HTR1FSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL8549211 | 0.78 | HTR1F (0.49) | HTR1FALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL8551309 | 0.78 | RAB9A (0.48) | HTR1FALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL8692074 | 0.78 | HPGD (0.45) | HTR1FALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8709033 | 0.77 | HTR1F (0.48) | HTR1FL3MBTL1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |