Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138773 | 0.84 | IMPDH2 (0.45) | HTR6ROCK1IKBKBJAK2ROCK2 | |
| SCHEMBL8550195 | 0.84 | MEN1 (0.44) | HTR6ROCK1IKBKBJAK2ROCK2 | |
| SCHEMBL8547927 | 0.75 | ROCK1 (0.37) | ROCK1ROCK2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8549554 | 0.73 | HTR6 (0.42) | HTR6LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12922863 | 0.67 | BRD4 (0.50) | HTR6LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10356533 | 0.67 | LMNA (0.69) | ROCK1IKBKBJAK2ROCK2JAK3 | |
| SCHEMBL8554008 | 0.65 | BRAF (0.30) | — | |
| SCHEMBL8191020 | 0.62 | HTR1F (0.42) | LMNASMN1; SMN2ALDH1A1ITK | |
| SCHEMBL8552127 | 0.62 | KDM4E (0.39) | ROCK1ROCK2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL17437173 | 0.62 | LMNA (0.56) | HTR6ROCK1IKBKBJAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |