Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552507 | 0.86 | DRD2 (0.39) | DRD2SLC6A4HTR1DHTR1BNPY5R | |
| SCHEMBL8551514 | 0.84 | ALDH1A1 (0.42) | DRD2SLC6A4P2RY1KCNH2 | |
| SCHEMBL7478032 | 0.83 | HTR1D (0.53) | DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL8551516 | 0.82 | DRD2 (0.40) | DRD2SLC6A4P2RY1KCNH2ADRA1A | |
| SCHEMBL8550058 | 0.80 | DRD2 (0.41) | DRD2SLC6A4ADRA1ANAMPTHTR1A | |
| SCHEMBL8552124 | 0.78 | DRD2 (0.43) | DRD2SLC6A4P2RY1KCNH2NAMPT | |
| SCHEMBL8552297 | 0.78 | DRD2 (0.48) | DRD2SLC6A4 | |
| SCHEMBL8547871 | 0.77 | HTR1D (0.43) | DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL8704937 | 0.77 | DRD2 (0.44) | DRD2SLC6A4P2RY1KCNH2NAMPT | |
| SCHEMBL8547896 | 0.75 | DRD2 (0.37) | DRD2SLC6A4ADRA1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |