Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 7/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489102 | 0.85 | HTR1D (0.47) | DRD2HTR1A | |
| SCHEMBL30908972 | 0.85 | HTR1D (0.47) | DRD2HTR1A | |
| SCHEMBL8552510 | 0.82 | DRD2 (0.40) | DRD2SLC6A4P2RY1KCNH2CHRM4 | |
| SCHEMBL8552507 | 0.81 | DRD2 (0.39) | DRD2SLC6A4NPY5R | |
| SCHEMBL8551514 | 0.80 | ALDH1A1 (0.42) | DRD2SLC6A4P2RY1KCNH2 | |
| SCHEMBL8550058 | 0.80 | DRD2 (0.41) | DRD2SLC6A4CHRM4HTR1AUBE2M | |
| SCHEMBL8547064 | 0.78 | DRD2 (0.46) | DRD2SLC6A4UBE2MDCUN1D1 | |
| SCHEMBL8551607 | 0.78 | DRD2 (0.57) | DRD2SLC6A4CHRM4UBE2MDCUN1D1 | |
| SCHEMBL8704937 | 0.77 | DRD2 (0.44) | DRD2SLC6A4P2RY1KCNH2CHRM4 | |
| SCHEMBL8552124 | 0.77 | DRD2 (0.43) | DRD2SLC6A4P2RY1KCNH2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |