SCHEMBL8550306

SCHEMBL8550306

Cc1ccc(C(=O)c2oc3cc(OCc4ccccc4)ccc3c2C)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.62
ACHE P22303 5/20 0.62
MAOA P21397 4/20 0.60
KDM4E B2RXH2 1/20 0.59
MEN1 O00255 1/20 0.59
ALDH1A1 P00352 1/20 0.59
KMT2A Q03164 1/20 0.59
CASP3 P42574 2/20 0.55
SENP8 Q96LD8 2/20 0.55
SENP7 Q9BQF6 2/20 0.55
SENP6 Q9GZR1 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
TUBB4A P04350 1/20 0.49
TUBB P07437 1/20 0.49
TUBA3C P0DPH7 1/20 0.49
TUBA1B P68363 1/20 0.49
TUBA4A P68366 1/20 0.49
TUBB4B P68371 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28208757 0.94 MAOB (0.66) MAOBACHEMAOAKDM4EMEN1
SCHEMBL28411136 0.91 CASP3 (0.57) MAOBACHEMAOAKDM4EMEN1
SCHEMBL8545664 0.87 KDM4E (0.53) MAOBACHEMAOAKDM4EMEN1
SCHEMBL28209630 0.85 CASP3 (0.61) MAOBACHEKDM4EMEN1ALDH1A1
SCHEMBL8545762 0.79 APP (0.45) MAOBACHEMAOAKDM4EMEN1
SCHEMBL8545761 0.79 APP (0.45) MAOBACHEMAOAKDM4EMEN1
SCHEMBL30608274 0.78 KDM4E (0.72) KDM4EMEN1ALDH1A1KMT2ATDP1
SCHEMBL31384139 0.78 RAB9A (0.61) MAOBKDM4EMEN1ALDH1A1KMT2A
SCHEMBL8545670 0.78 SLC26A3 (0.48) MAOBMAOAKDM4EMEN1ALDH1A1
SCHEMBL7432074 0.77 ACHE (1.00) MAOBACHEMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107935972-B 5- [ 2-hydroxy-3- (isopropylamino) propoxy ] benzofuran derivative and application thereof 沈阳药科大学 2020-06-02 CN disclosed
EP-0623607-B1 Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives BAYER AG (DE) 1998-07-15 EP disclosed
US-5504213-A ANTIINFLAMMATORY AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1996-04-02 US disclosed
EP-0623607-A1 Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives BAYER AG (DE) 1994-11-09 EP disclosed