Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552785 | 0.92 | LMNA (0.49) | LMNACYP1A2CYP2D6CACNA1BMAPT | |
| SCHEMBL8361641 | 0.90 | LMNA (0.49) | LMNACYP1A2CYP2D6MAPTPPARD | |
| SCHEMBL8551252 | 0.88 | LMNA (0.50) | LMNACYP1A2CYP2D6CACNA1BCACNA1H | |
| SCHEMBL8551381 | 0.82 | CACNA1B (0.45) | LMNACYP1A2CYP2D6CACNA1BCACNA1H | |
| SCHEMBL8355833 | 0.82 | THRB (0.40) | PPARGPPARDPPARABCHE | |
| SCHEMBL8359111 | 0.81 | CACNA1B (0.53) | LMNACYP1A2CYP2D6CACNA1BCACNA1H | |
| SCHEMBL8357762 | 0.80 | LMNA (0.49) | LMNACYP1A2CYP2D6MAPTPPARD | |
| SCHEMBL8551665 | 0.79 | CACNA1B (0.47) | LMNACYP1A2CYP2D6CACNA1BCACNA1H | |
| SCHEMBL8359973 | 0.78 | LMNA (0.60) | LMNACYP1A2CYP2D6CACNA1BMAPT | |
| SCHEMBL8516569 | 0.78 | MAPT (0.44) | LMNACYP1A2CYP2D6CACNA1BCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824529-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035681-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-11-14 | — | — | WO | disclosed |