Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549896 | 0.76 | CHRNB2 (0.45) | ALDH1A1MEN1KMT2AESR1ESR2 | |
| SCHEMBL8549856 | 0.73 | ALDH1A1 (0.33) | ALDH1A1HTTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL7484667 | 0.71 | ALDH1A1 (0.42) | ALDH1A1ACHEHTTSMN1; SMN2MEN1 | |
| SCHEMBL10580640 | 0.70 | ALDH1A1 (0.41) | ALDH1A1HTTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL1064809 | 0.69 | ALDH1A1 (0.47) | ALDH1A1NPSR1BCHEACHEHTT | |
| SCHEMBL1979879 | 0.68 | PARP1 (0.41) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL29814297 | 0.68 | GPR35 (0.43) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8550301 | 0.68 | GPR35 (0.41) | ALDH1A1HTTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL15427979 | 0.68 | ALDH1A1 (0.48) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8550097 | 0.68 | GPR35 (0.43) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736025-B1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-22 | — | — | EP | disclosed |
| US-5700818-A | Dihydrobenzofuranyl-biphenyl carboxamides having 5HT1D antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0736025-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT 1D? ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017401-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |