Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | MTTP | P55157 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704365 | 0.88 | DRD2 (0.42) | DRD2SLC6A4MAPTTP53POLB | |
| SCHEMBL7481469 | 0.83 | HTR1D (0.52) | DRD2HTR1DHTR1B | |
| SCHEMBL8547778 | 0.83 | DRD2 (0.41) | DRD2SLC6A4MAPTRAB9ANPC1 | |
| SCHEMBL8552293 | 0.82 | LMNA (0.42) | DRD2SLC6A4MAPTNPSR1MEN1 | |
| SCHEMBL8548010 | 0.80 | DRD2 (0.40) | DRD2SLC6A4MAPTTP53POLB | |
| SCHEMBL8552356 | 0.80 | DRD2 (0.39) | DRD2SLC6A4CHRM4 | |
| SCHEMBL8552196 | 0.79 | HTR1D (0.34) | DRD2SLC6A4MAPTCHRM4HTR1D | |
| SCHEMBL8553071 | 0.77 | KMT2A (0.47) | MAPTTP53RAB9ASMN1; SMN2GAA | |
| SCHEMBL8708863 | 0.77 | UBE2M (0.47) | — | |
| SCHEMBL8553038 | 0.75 | UBE2M (0.42) | MAPTTP53POLBBLMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |