Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 13/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 13/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704365 | 0.84 | DRD2 (0.42) | DRD2SLC6A4UBE2MDCUN1D1CHRM4 | |
| SCHEMBL7481470 | 0.83 | HTR1D (0.52) | — | |
| SCHEMBL8547782 | 0.83 | DRD2 (0.41) | DRD2SLC6A4UBE2MDCUN1D1 | |
| SCHEMBL8552293 | 0.80 | LMNA (0.42) | DRD2SLC6A4 | |
| SCHEMBL8548010 | 0.80 | DRD2 (0.40) | DRD2SLC6A4CHRM4RORC | |
| SCHEMBL8552355 | 0.80 | DRD2 (0.37) | DRD2SLC6A4CHRM4 | |
| SCHEMBL8550775 | 0.79 | UBE2M (0.38) | DRD2SLC6A4UBE2MDCUN1D1 | |
| SCHEMBL8551607 | 0.78 | DRD2 (0.57) | DRD2SLC6A4UBE2MDCUN1D1CHRM4 | |
| SCHEMBL8548444 | 0.78 | ALDH1A1 (0.39) | DRD2SLC6A4UBE2MDCUN1D1OPRD1 | |
| SCHEMBL8553071 | 0.77 | KMT2A (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |