Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590974 | 0.91 | L3MBTL1 (0.44) | LMNATHRBL3MBTL1POLBTP53 | |
| SCHEMBL8549545 | 0.88 | L3MBTL1 (0.43) | LMNATHRBL3MBTL1POLBEPHX1 | |
| SCHEMBL8551331 | 0.84 | POLB (0.43) | LMNATHRBL3MBTL1POLBEPHX1 | |
| Hydrochloric Acid SCHEMBL8592818 | 0.82 | SMYD3 (0.41) | — | |
| SCHEMBL8552358 | 0.82 | GLS (0.46) | — | |
| SCHEMBL8553949 | 0.80 | LMNA (0.45) | LMNATHRBTP53MAPT | |
| SCHEMBL8625016 | 0.79 | KDM4E (0.49) | LMNATP53MAPT | |
| SCHEMBL8550488 | 0.77 | KDM4E (0.44) | THRBEPHX1MAPT | |
| SCHEMBL8553067 | 0.76 | GLS (0.38) | THRBTP53MAPT | |
| SCHEMBL8553020 | 0.75 | THRB (0.46) | THRBPOLBEPHX1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |