Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606668 | 0.85 | KDM4E (0.55) | AGTR1AGTR2ALDH1A1HSD17B10MAPT | |
| SCHEMBL9199570 | 0.72 | ALDH1A1 (0.39) | AGTR1AGTR2ALDH1A1HSD17B10MAPT | |
| SCHEMBL8944112 | 0.71 | AGTR1 (0.62) | AGTR1AGTR2ALDH1A1HSD17B10MAPT | |
| SCHEMBL9031742 | 0.71 | BDKRB1 (0.37) | ALDH1A1HSD17B10MAPTKDM4EBDKRB1 | |
| SCHEMBL9197854 | 0.69 | ALDH1A1 (0.39) | AGTR1AGTR2ALDH1A1HSD17B10MAPT | |
| SCHEMBL8553595 | 0.69 | LTB4R2 (0.45) | AGTR1AGTR2ALDH1A1MAPTKDM4E | |
| SCHEMBL9039532 | 0.68 | MYC (0.32) | BDKRB1CYP1A2 | |
| SCHEMBL9031434 | 0.68 | MYC (0.39) | ALDH1A1HSD17B10MAPTKDM4EBDKRB1 | |
| SCHEMBL9033745 | 0.68 | ACHE (0.32) | AGTR1AGTR2BDKRB1MEN1KMT2A | |
| SCHEMBL8550700 | 0.68 | KDM4E (0.49) | AGTR1AGTR2ALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |