Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557469 | 0.89 | PDE3B (0.52) | PDE3BPDE3ACNR1SMN1; SMN2MAPT | |
| SCHEMBL7707823 | 0.82 | ALOX5 (0.44) | PDE3BPDE3ACNR1SMN1; SMN2MAPT | |
| SCHEMBL8557456 | 0.79 | LMNA (0.48) | PDE3BPDE3ASMN1; SMN2MAPTLMNA | |
| SCHEMBL8551933 | 0.79 | PDE3B (0.51) | PDE3BPDE3ACNR1SMN1; SMN2MAPT | |
| SCHEMBL8557542 | 0.78 | LMNA (0.42) | PDE3BPDE3ASMN1; SMN2MAPTLMNA | |
| SCHEMBL251645 | 0.78 | ALOX5 (0.43) | PDE3BPDE3ASMN1; SMN2MAPTLMNA | |
| SCHEMBL8555747 | 0.78 | PLK1 (0.39) | PDE3BPDE3ACNR1SMN1; SMN2LMNA | |
| SCHEMBL8554381 | 0.76 | PDE3B (0.48) | PDE3BPDE3ACNR1SMN1; SMN2MAPT | |
| SCHEMBL7424550 | 0.75 | ALOX5 (0.39) | PDE3BPDE3ACNR1SMN1; SMN2LMNA | |
| SCHEMBL8553605 | 0.71 | ALOX5 (0.48) | PDE3BPDE3ASMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |