Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557456 | 0.85 | LMNA (0.48) | LMNAMAPK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL7707823 | 0.81 | ALOX5 (0.44) | LMNAMAPK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL251645 | 0.79 | ALOX5 (0.43) | LMNAMAPK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL8553612 | 0.78 | PDE3B (0.43) | LMNAPDE3BPDE3ASMN1; SMN2GRIN1 | |
| SCHEMBL8551838 | 0.74 | LMNA (0.55) | LMNAMAPK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL8556569 | 0.73 | ROCK2 (0.63) | LMNAMAPK1ALDH1A1PKMHTT | |
| SCHEMBL8555747 | 0.72 | PLK1 (0.39) | LMNAPDE3BPDE3ASMN1; SMN2GRIN1 | |
| SCHEMBL7424550 | 0.72 | ALOX5 (0.39) | LMNAPDE3BPDE3AALDH1A1SMN1; SMN2 | |
| SCHEMBL8553605 | 0.70 | ALOX5 (0.48) | LMNAMAPK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL8551585 | 0.69 | SMN1; SMN2 (0.48) | LMNAMAPK1PDE3BPDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |