Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552451 | 0.90 | CCR5 (0.39) | CCR5ALOX5NPC1SIGMAR1OPRK1 | |
| SCHEMBL8550876 | 0.89 | CCR5 (0.42) | CCR5KCNQ2SIGMAR1OPRK1OPRM1 | |
| SCHEMBL8551503 | 0.88 | NOTUM (0.41) | KCNQ2SIGMAR1NOTUM | |
| SCHEMBL8547874 | 0.87 | GPBAR1 (0.40) | CCR5NOTUMDRD2DRD4 | |
| SCHEMBL8552339 | 0.86 | NOTUM (0.44) | CCR5KCNQ2SIGMAR1NOTUMDRD2 | |
| SCHEMBL8551859 | 0.85 | ALOX5 (0.36) | ALOX5OPRK1OPRM1OPRD1DRD2 | |
| SCHEMBL8701795 | 0.80 | LTB4R (0.43) | CCR5SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL27489261 | 0.78 | SIGMAR1 (0.39) | CCR5KCNQ2SIGMAR1OPRK1NPBWR1 | |
| SCHEMBL16333452 | 0.77 | KCNH2 (0.47) | CCR5SIGMAR1OPRK1PTGDR2 | |
| SCHEMBL6472157 | 0.74 | OPRK1 (0.54) | OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817772-A1 | PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS | PFIZER INC. (US) | 1998-01-14 | — | — | EP | claimed |