Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 2/20 | 0.41 |
| ▸ | CCKBR | P32239 | 9/20 | 0.40 |
| ▸ | CCKAR | P32238 | 5/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550878 | 0.86 | CCKBR (0.45) | OXTRCCKBRCCKARALDH1A1 | |
| SCHEMBL8798046 | 0.77 | SENP1 (0.52) | CCKBRCCKARALDH1A1SENP1 | |
| SCHEMBL8552734 | 0.76 | POLB (0.44) | CCKBRCCKARALDH1A1 | |
| SCHEMBL8553890 | 0.76 | CCKBR (0.67) | CCKBRCCKAR | |
| SCHEMBL8555479 | 0.75 | CCKBR (0.43) | OXTRCCKBRCCKAR | |
| SCHEMBL8547267 | 0.74 | CCKBR (0.57) | CCKBRCCKARSENP1 | |
| SCHEMBL8597611 | 0.74 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL8545924 | 0.74 | SENP1 (0.52) | OXTRCCKBRCCKARSENP1 | |
| SCHEMBL9592825 | 0.73 | CCKBR (0.63) | CCKBRCCKARSENP1 | |
| SCHEMBL8555248 | 0.70 | OXTR (0.41) | OXTRCCKBRCCKARPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672037-B1 | 1,4-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS CCK-MODULATORS | GLAXO GROUP LTD (GB) | 1998-07-08 | — | — | EP | disclosed |
| US-5569654-A | ADMINISTERING AS ANTAGONISTS OF GASTRIN AND CHOLECYSTOKININ | GLAXO GROUP LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |