Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18650482 | 0.77 | HSD17B3 (0.34) | TSHRSRD5A1DRD4CHRM2CHRM4 | |
| SCHEMBL13305787 | 0.75 | CHRNB2 (0.44) | TSHRPKMHPGDNPSR1GRIN2B | |
| SCHEMBL10683163 | 0.75 | CHRNB2 (0.44) | TSHRPKMHPGDNPSR1GRIN2B | |
| SCHEMBL8554748 | 0.75 | TSHR (0.42) | TSHRPKMHPGDNPSR1GRIN2B | |
| SCHEMBL29746320 | 0.74 | PDK1 (0.48) | TSHRPKMHPGDNPSR1PDK1 | |
| SCHEMBL11765796 | 0.73 | TSHR (0.48) | TSHRPKMHPGDNPSR1GRIN2B | |
| SCHEMBL8522803 | 0.72 | PDK1 (0.46) | TSHRPKMHPGDNPSR1PDK1 | |
| SCHEMBL8522807 | 0.71 | PDK1 (0.43) | TSHRPKMHPGDNPSR1GRIN2B | |
| SCHEMBL2349047 | 0.71 | ALDH1A1 (0.42) | DRD4DRD2 | |
| SCHEMBL6414797 | 0.70 | LMNA (0.53) | HPGDNPSR1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| EP-0725068-A1 | INDOLE DERIVATIVE | TOKYO TANABE COMPANY LIMITED (JP) | 1996-08-07 | — | — | EP | disclosed |
| US-5324725-A | Antiinflammatory agent, antiallergen | KALI-CHEMIE PHARMA GMBH (DE) | 1994-06-28 | — | — | US | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |