Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | RXRA | P19793 | 2/20 | 0.52 |
| ▸ | RXRB | P28702 | 2/20 | 0.52 |
| ▸ | RXRG | P48443 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | OGA | O60502 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553993 | 0.93 | KDR (0.54) | ATMKDRRXRARXRBRXRG | |
| SCHEMBL8554363 | 0.91 | KDR (0.57) | ATMKDRRXRARXRBOGA | |
| SCHEMBL8556969 | 0.90 | REV1 (0.53) | ATMKDRACHEBACE1OGA | |
| SCHEMBL8557154 | 0.87 | KDR (0.60) | KDROGAMEN1KMT2AKCNA5 | |
| SCHEMBL8554568 | 0.86 | KDR (0.58) | ATMKDRRXRARXRBRXRG | |
| SCHEMBL8553599 | 0.83 | KDR (0.48) | KDRRXRARXRBRXRGACHE | |
| SCHEMBL8552887 | 0.82 | NR4A2 (0.47) | KDRRXRARXRBRXRGMEN1 | |
| SCHEMBL8554274 | 0.80 | KDR (0.45) | KDRACHEBACE1ALDH1A1MAPT | |
| SCHEMBL18409351 | 0.79 | ALDH1A1 (0.54) | KDRRXRARXRBRXRGALDH1A1 | |
| SCHEMBL18409735 | 0.77 | KCNH2 (0.58) | RXRARXRBRXRGALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582164-B1 | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles | BRISTOL MYERS SQUIBB CO (US) | 1998-12-23 | — | — | EP | claimed |
| US-5382584-A | Antiischemic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-01-17 | — | — | US | claimed |
| EP-0582164-A1 | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles | Bristol-Myers Squibb Company (US) | 1994-02-09 | — | — | EP | claimed |