Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556676 | 0.83 | ALOX5 (0.38) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8558633 | 0.80 | ALOX5 (0.40) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL8627726 | 0.80 | ALOX5 (0.40) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL6930961 | 0.79 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7421254 | 0.71 | PTGES (0.41) | SMN1; SMN2PPARGPTGESNR1I3 | |
| SCHEMBL8551585 | 0.70 | SMN1; SMN2 (0.48) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL251645 | 0.70 | ALOX5 (0.43) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8555588 | 0.69 | SMN1; SMN2 (0.47) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8554409 | 0.69 | LMNA (0.47) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8554263 | 0.67 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |