Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.38 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555068 | 0.93 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASLC40A1KDM4E | |
| SCHEMBL8560073 | 0.90 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASLC40A1KDM4E | |
| SCHEMBL8556679 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNACCNT1CDK9 | |
| SCHEMBL8554061 | 0.87 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNASLC40A1KDM4E | |
| SCHEMBL8557951 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNACCNT1CDK9 | |
| SCHEMBL8555983 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNASLC40A1KDM4E | |
| SCHEMBL8555336 | 0.85 | MAPT (0.44) | ALDH1A1MAPTLMNACCNT1CDK9 | |
| SCHEMBL8559468 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNASLC40A1POLB | |
| SCHEMBL8561122 | 0.84 | MAPT (0.44) | ALDH1A1MAPTLMNASLC40A1POLB | |
| SCHEMBL8560880 | 0.82 | MAPT (0.48) | ALDH1A1MAPTLMNACCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |