Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559038 | 0.90 | ALDH1A1 (0.53) | RIPK1MAPTNPBWR1RAB9ANPC1 | |
| SCHEMBL8554234 | 0.80 | MAPT (0.56) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7209149 | 0.79 | ALDH1A1 (0.59) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6773598 | 0.77 | RIPK1 (1.00) | RIPK1MAPTNPBWR1RAB9ANPC1 | |
| SCHEMBL8559255 | 0.74 | MAPT (0.73) | RIPK1MAPTNPBWR1RAB9ANPC1 | |
| SCHEMBL2245102 | 0.72 | NPBWR1 (1.00) | MAPTNPBWR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31679090 | 0.72 | NPBWR1 (1.00) | MAPTNPBWR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8554228 | 0.72 | XDH (0.46) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20380076 | 0.71 | HTT (0.64) | MAPTRAB9ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL1171437 | 0.71 | NPC1 (0.82) | MAPTNPBWR1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |