Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557996 | 0.91 | MAPT (0.46) | SMN1; SMN2ALDH1A1MAPTRXRARXRB | |
| SCHEMBL8557471 | 0.89 | MAPT (0.48) | MEN1KMT2APTPN2PTPN1PTPN5 | |
| SCHEMBL8560574 | 0.88 | MAPT (0.46) | MEN1KMT2AL3MBTL1PTPN2PTPN1 | |
| SCHEMBL8556998 | 0.87 | PTPN1 (0.44) | MEN1KMT2APTPN2PTPN1PTPN5 | |
| SCHEMBL8558253 | 0.87 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL8556146 | 0.87 | PGR (0.50) | PTPN2PTPN1ALDH1A1MAPTRXRA | |
| SCHEMBL8561015 | 0.86 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL8558562 | 0.84 | MAPT (0.43) | KMT2AALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL8559699 | 0.84 | MAPT (0.43) | SMN1; SMN2ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL8559236 | 0.84 | KMT2A (0.47) | KMT2ASMN1; SMN2ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |