Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP10 | P09238 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697550 | 0.85 | HRH1 (0.43) | GPR119MMP7MMP8MMP12SMN1; SMN2 | |
| SCHEMBL8566265 | 0.83 | GPR119 (0.41) | GPR119MMP7MMP8MMP12SMN1; SMN2 | |
| SCHEMBL8565877 | 0.78 | HSD11B1 (0.46) | SMN1; SMN2GAAMAPK1MAPTPKM | |
| SCHEMBL2774814 | 0.78 | LMNA (0.47) | GPR119SMN1; SMN2GAATHRBMAPK1 | |
| SCHEMBL8567057 | 0.75 | ALDH1A1 (0.46) | MMP7MMP8MMP12SMN1; SMN2GAA | |
| SCHEMBL8561156 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2MAPK1MAPTKDM4E | |
| SCHEMBL8566268 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2MAPK1MAPTKDM4E | |
| SCHEMBL8561759 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2GAAMAPK1MAPTKDM4E | |
| SCHEMBL8565649 | 0.74 | ALDH1A1 (0.44) | SMN1; SMN2GAATHRBMAPK1MAPT | |
| Sulfamic Acid Cyclohexyl Ester SCHEMBL9302699 | 0.73 | MAPK1 (0.41) | SMN1; SMN2MAPK1MAPTKDM4EMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539421-B1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-23 | — | — | EP | disclosed |
| US-5278165-A | Oxazolyl imidazol[4,5-b]pyridin and pyrimidine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| US-5217980-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-08 | — | — | US | disclosed |
| EP-0539421-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001687-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |