Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262676 | 0.79 | KDM4E (0.44) | SLC6A4HTR2AKCNH2L3MBTL1MAPT | |
| SCHEMBL5583834 | 0.77 | ALDH1A1 (0.37) | SLC6A4HTR2AKCNH2L3MBTL1MAPT | |
| SCHEMBL8563171 | 0.77 | PPARG (0.33) | SLC6A4PPARGARPPARDPPARA | |
| SCHEMBL10961574 | 0.77 | GABRA1 (0.46) | HTR2APPARGPPARDPPARAATM | |
| SCHEMBL15429150 | 0.76 | SLC6A4 (0.47) | SLC6A4HTR2AKCNH2PPARGAR | |
| SCHEMBL21523926 | 0.75 | ATM (0.42) | PPARGPPARDPPARAATML3MBTL1 | |
| SCHEMBL7609083 | 0.74 | RAB9A (0.49) | SLC6A4HTR2AKCNH2PPARGAR | |
| SCHEMBL2261897 | 0.71 | NCOA1 (0.39) | SLC6A4HTR2AARL3MBTL1MAPT | |
| SCHEMBL9618788 | 0.71 | SLC6A4 (0.40) | SLC6A4HTR2AKCNH2PPARGAR | |
| SCHEMBL1282313 | 0.70 | MAPT (0.61) | L3MBTL1MAPTLMNAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |