Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | FADS1 | O60427 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568619 | 1.00 | ROCK2 (0.56) | ROCK2MAPTKMT2AMCHR1MGLL | |
| SCHEMBL8563690 | 0.90 | ROCK2 (0.48) | ROCK2MAPTKMT2AMCHR1DRD2 | |
| SCHEMBL14301512 | 0.82 | ROCK2 (0.53) | ROCK2MAPTKMT2AMCHR1MGLL | |
| SCHEMBL8285848 | 0.82 | ROCK2 (0.53) | ROCK2MAPTKMT2AMCHR1MGLL | |
| SCHEMBL8788607 | 0.82 | DRD2 (0.50) | ROCK2MCHR1DRD2DRD3KCNH2 | |
| SCHEMBL28758908 | 0.80 | GAA (0.55) | MAPTKMT2AGAA | |
| SCHEMBL892517 | 0.79 | ROCK2 (0.53) | ROCK2MAPTKMT2AMCHR1MGLL | |
| SCHEMBL892458 | 0.79 | ROCK2 (0.53) | ROCK2MAPTKMT2AMCHR1MGLL | |
| SCHEMBL8560581 | 0.79 | FADS1 (0.45) | ROCK2MAPTKMT2AMGLLDRD2 | |
| SCHEMBL8560582 | 0.79 | FADS1 (0.45) | ROCK2MAPTKMT2AMGLLDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |